Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians
with Alzheimer's Disease 
   Lead Investigator:    Umesh Gangishetti
   Institution      :    Emory University
   E-Mail           :    umesh.gangishetti@emory.edu
   Proposal ID      :    979


   Publications:


1  Kamara DM, Gangishetti U, Gearing M, Willis-Parker M, Zhao L, Hu WT, Walker LC
   Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease
   Journal Article  J Alzheimers Dis,62:1815-1826,2018,PMC6103628

   PUBLISHED





   Proposal Description:
   To determine if Cerebral amyloid angiopathy (CAA) differs between African americans(AA) and Caucasians. Although CAA occurs to some extent in nearly all AD patients, the degree of involvement varies widely, and it is considered severe in approximately 20 of cases. An earlier study provided suggestive evidence that CAA might be more common in African-Americans than in white individuals, but the difference between the groups was not statistically significant, and the prevalence of CAA in the white subjects was lower than expected based on the prior literature. In light of the elevated incidence and prevalence of clinical AD and lobar hemorrhage among African-Americans, along with the established link between lobar hemorrhage and CAA, we hypothesize that CAA might be particularly prevalent in African-Americans with end stage AD, and that this vulnerability contributes to their elevated susceptibility to dementia.